Lamprey immune protein-1 (LIP-1) from Lampetra japonica induces cell cycle arrest and cell death in HeLa cells.

@article{Chi2018LampreyIP,
  title={Lamprey immune protein-1 (LIP-1) from Lampetra japonica induces cell cycle arrest and cell death in HeLa cells.},
  author={Xiaoyuan Chi and P. W. Su and Dan Bi and Zhao Tai and Yingying Li and Yue Pang and Qingwei Li},
  journal={Fish & shellfish immunology},
  year={2018},
  volume={75},
  pages={
          295-300
        }
}
The lamprey (Lampetra japonica), a representative of the jawless vertebrates, is the oldest extant species in the world. LIP-1, which has a jacalin-like domain and an aerolysin pore-forming domain, has previously been identified in Lampetra japonica. However, the structure and function of the LIP-1 protein have not been described. In this study, the LIP-1 gene was overexpressed in HeLa cells and H293T cells. The results showed that the overexpression of LIP-1 in HeLa cells significantly… CONTINUE READING

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