Lamotrigine. A review of its use in childhood epilepsy.

@article{Culy2000LamotrigineAR,
  title={Lamotrigine. A review of its use in childhood epilepsy.},
  author={Christine R. Culy and Karen L. Goa},
  journal={Paediatric drugs},
  year={2000},
  volume={2 4},
  pages={
          299-330
        }
}
UNLABELLED Lamotrigine is an antiepileptic agent that blocks use-dependent voltage-sensitive sodium channels, thereby preventing excitatory neurotransmitter release. However, this mechanism does not explain the broad range of clinical efficacy of this agent. In noncomparative trials, adjunctive lamotrigine (< or = 15 mg/kg/day) improved seizure control in children and adolescents with various refractory seizure types, with about 29 to 90% of patients showing a > or = 50% reduction in seizure… CONTINUE READING
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