Lamotrigine in treatment-resistant schizophrenia: a randomized placebo-controlled crossover trial.

@article{Tiihonen2003LamotrigineIT,
  title={Lamotrigine in treatment-resistant schizophrenia: a randomized placebo-controlled crossover trial.},
  author={Jari Tiihonen and Tero Hallikainen and Olli-Pekka Ryyn{\"a}nen and Eila Repo-Tiihonen and Irma Kotilainen and Markku Eronen and P. M. A. Toivonen and Kristian Wahlbeck and Anu Putkonen},
  journal={Biological psychiatry},
  year={2003},
  volume={54 11},
  pages={1241-8}
}
BACKGROUND There is no evidence from randomized, controlled trials that demonstrate effectiveness for any pharmacological treatment in clozapine-resistant schizophrenia. Since the introduction of chlorpromazine, all antipsychotics with proven efficacy on positive symptoms have been dopamine antagonists, but recent experimental data suggest that ketamine-induced positive schizophreniform symptoms in healthy subjects can be controlled by a glutamate antagonist lamotrigine. The hypothesis tested… CONTINUE READING
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