Lamotrigine concentrations in human serum, brain tissue, and tumor tissue.

@article{Meyer1999LamotrigineCI,
  title={Lamotrigine concentrations in human serum, brain tissue, and tumor tissue.},
  author={F. P. Meyer and Peter Banditt and Armin Schubert and J Sch{\"o}che},
  journal={Epilepsia},
  year={1999},
  volume={40 1},
  pages={68-73}
}
PURPOSE Although lamotrigine (LTG) has been used for years as an antiepilepic drug (AED), there are no data on penetration into the brain with the exception of a single case report. It was our aim to determine the LTG content in the brain and the tumor tissue and to bring the same into relation to the serum concentration and protein binding in neurosurgically operated patients. METHODS Neurosurgical intervention was performed on 11 patients with brain tumors. Tumor tissue was removed, and LTG… CONTINUE READING

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