Lamotrigine-associated rash: risk/benefit considerations in adults and children.

  title={Lamotrigine-associated rash: risk/benefit considerations in adults and children.},
  author={Ainat Guberman and Frank M.C. Besag and Martin J Brodie and Joseph M. Dooley and Michael S. Duchowny and J M Pellock and Alan Richens and R S Stern and Edwin Trevathan},
  volume={40 7},
PURPOSE Lamotrigine (LTG) is an antiepileptic drug (AED) recently released in several countries. It is effective for a variety of seizure types in adults and children both as an add-on agent and in monotherapy, and is generally well tolerated. This report reviews the apparent risk factors for rash associated with LTG to determine whether and how the risk of serious rash can be minimized in practice. METHODS The panel of experts reviewed all published and unpublished data related to the… CONTINUE READING