Lamotrigine as an Add-on Treatment for Depersonalization Disorder: A Retrospective Study of 32 Cases

@article{Sierra2006LamotrigineAA,
  title={Lamotrigine as an Add-on Treatment for Depersonalization Disorder: A Retrospective Study of 32 Cases},
  author={Mauricio Sierra and Dawn L. Baker and Nick Medford and Emma J. Lawrence and Maxine X. Patel and Mary L. Phillips and Anthony S. David},
  journal={Clinical Neuropharmacology},
  year={2006},
  volume={29},
  pages={253-258}
}
Objectives: Depersonalization disorder (DPD) is a chronic condition characterized by the persistent subjective experience of unreality and detachment from the self. To date, there is no known treatment. Lamotrigine as sole agent was not found to be effective in a previous small double-blind, randomized crossover trial. However, evidence from open trials suggests that it may be beneficial as an add-on medication with antidepressants. Methods: We report here an extended series of 32 patients with… 
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A Case of Depersonalization with Treatment-resistant Depression Successfully Treated with Sertraline-lamotrigine Combination.
TLDR
It is suggested that augmentation of sertraline with lamotrigine may have been the key ingredient in this patient's recovery of depersonalization with treatment-resistant depression.
Depersonalization disorder: pharmacological approaches
  • M. Sierra
  • Psychology, Medicine
    Expert review of neurotherapeutics
  • 2008
TLDR
A number of studies suggest that opioid receptor antagonists such as naltrexone and naloxone are useful in at least a subgroup of patients, and those neurotransmitter systems of relevance to depersonalization are known to play important inhibitory roles in the regulation of the stress response.
The efficacy of lamotrigine in a resistant case of depersonalization disorder.
TLDR
A resistant case that responded to lamotrigine is presented, among the many psychoactive drugs studied, none of them has been shown to be the treatment of choice.
Evidence-based treatment for Depersonalisation-derealisation Disorder (DPRD)
TLDR
The limited data from randomised controlled trials on the pharmacotherapy and psychotherapy of DPRD demonstrates inconsistent evidence for the efficacy of lamotrigine, and no efficacy for other interventions.
Methylphenidate in depersonalization disorder: a case report.
TLDR
A case that responded spectacularly to methylphenidate is presented, with virtually no evidence, and among the many psychoactive drugs studied, none of them has been shown to be the treatment of choice.
Treatment of Depersonalization Disorder With Repetitive Transcranial Magnetic Stimulation.
TLDR
The case of a 30-year-old man with major depressive disorder and DPD who did not respond to pharmacotherapy is presented, and there was a significant reduction in his depersonalization symptoms after the patient was treated with low frequency rTMS to the right DLPFC followed by high frequency r tms to the left DLP FC.
Lamotrigine Uses in Psychiatric Practice-Beyond Bipolar Prophylaxis a Hope or Hype?
TLDR
Level of evidence supporting the use of LAM in off-label indications is highly variable, and hence, sound clinical judgment is necessary for its proper use and placement in real-life psychiatric practice and psychopharmacotherapy algorithms.
Depersonalization disorder
TLDR
Greater understanding of the clinical characteristics of this disorder will improve the reliability of diagnosis and aid the development of neurobiological and psychological models for empirical testing.
El metilfenidato en el trastorno por despersonalización: a propósito de un caso
TLDR
A case that responded spectacularly to methylphenidate is presented, with virtually no evidence, and among the many psychoactive drugs studied, none of them has been shown to be the treatment of choice.
Depersonalisation and derealisation: assessment and management
TLDR
Clinicians are urged to help clinicians recognise depersonalisation and derealisation (DP DR) symptoms, diagnose the disorder, and discuss current treatment options.
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