Lamotrigine as an Add-on Treatment for Depersonalization Disorder: A Retrospective Study of 32 Cases

@article{Sierra2006LamotrigineAA,
  title={Lamotrigine as an Add-on Treatment for Depersonalization Disorder: A Retrospective Study of 32 Cases},
  author={Mauricio Sierra and Dawn L. Baker and Nick Medford and Emma J. Lawrence and Maxine X. Patel and Mary L. Phillips and Anthony S. David},
  journal={Clinical Neuropharmacology},
  year={2006},
  volume={29},
  pages={253-258}
}
Objectives: Depersonalization disorder (DPD) is a chronic condition characterized by the persistent subjective experience of unreality and detachment from the self. To date, there is no known treatment. Lamotrigine as sole agent was not found to be effective in a previous small double-blind, randomized crossover trial. However, evidence from open trials suggests that it may be beneficial as an add-on medication with antidepressants. Methods: We report here an extended series of 32 patients with… 

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References

SHOWING 1-10 OF 42 REFERENCES

Fluoxetine therapy in depersonalisation disorder: Randomised controlled trial

Fluoxetine was not efficacious in treating depersonalisation disorder, despite the commonly reported clinical use of serotonin reuptake inhibitors for this condition.

Lamotrigine as adjunct to paroxetine in acute depression: a placebo-controlled, double-blind study.

Lamotrigine might have antidepressive properties in unipolar patients and may accelerate onset of action when given in combination with typical antidepressants.

Feeling unreal: a depersonalization disorder update of 117 cases.

The characteristics of depersonalization disorder found in this sample, the largest described to date, are in good accord with previous literature, and the study highlights the need for novel therapeutic approaches to treat depersonALization disorder.

Depersonalisation disorder: clinical features of 204 cases

Depersonalisation disorder is a recognisable clinical entity but appears to have significant comorbidity with anxiety and depression and research into its aetiology and treatment is warranted.

Chronic depersonalization following illicit drug use: a controlled analysis of 40 cases.

Drug-induced DP does not appear to represent a distinct clinical syndrome, and the neurocognitive mechanisms of the genesis and maintenance of DP are likely to be similar across clinical groups, regardless of precipitants.

Treatment of Depersonalization with Serotonin: Reuptake Blockers

The chronicity of illness and lack of prior response to a variety of treatments in these patients highlights the positive outcome with this treatment and issues are raised regarding the current hierarchical exclusion of depersonalization disorder in the presence of obsessive-compulsive and panic disorders.

The Cambridge Depersonalization Scale: a new instrument for the measurement of depersonalization.

The Cambridge Depersonalization Scale is meant to capture the frequency and duration of depersonalized symptoms over the 'last 6 months' and showed high internal consistency and good reliability, and can be profitably used in both clinical and neurobiological research.