Lamotrigine and valproic acid have different effects on motorcortical neuronal excitability

@article{Li2009LamotrigineAV,
  title={Lamotrigine and valproic acid have different effects on motorcortical neuronal excitability},
  author={Xingbao Li and Raffaella Ricci and Charles H. Large and Berry S. Anderson and Ziad Nahas and Mark S. George},
  journal={Journal of Neural Transmission},
  year={2009},
  volume={116},
  pages={423-429}
}
To investigate different cortical effects of lamotrigine and valproic acid, 30 paid healthy adult men were given, in a randomized/blinded fashion on three separate days (separated by a week), either a single dose of lamotrigine 325 mg, or a single dose of valproic acid 1,250 mg, or placebo. Resting motor threshold (RMT), cortical silent period (CSP) and motor evoked potential recruitment curves (RC) were assessed at baseline and 3 h after administration of each medication (or placebo… CONTINUE READING

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