Lamivudine prevents reactivation of hepatitis B and reduces mortality in immunosuppressed patients: systematic review and meta‐analysis
@article{Katz2008LamivudinePR, title={Lamivudine prevents reactivation of hepatitis B and reduces mortality in immunosuppressed patients: systematic review and meta‐analysis}, author={Lior H Katz and Abigail Fraser and Anat Gafter-Gvili and Leonard Leibovici and Ran Tur-kaspa}, journal={Journal of Viral Hepatitis}, year={2008}, volume={15} }
Summary. To assess the effects of prophylactic lamivudine on reactivation and mortality following immunosuppressive therapy in hepatitis B surface antigen (HBsAg)‐positive patients, we performed a meta‐analysis. Systematic review and meta‐analysis of randomized and nonrandomized prospective controlled trials and retrospective comparative case series were identified through The Cochrane Hepato‐Biliary Group Controlled Trials Register, The Cochrane Central Register of Controlled Trials, MEDLINE…
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References
SHOWING 1-10 OF 82 REFERENCES
Lamivudine for the prevention of hepatitis B virus reactivation in hepatitis B s-antigen seropositive cancer patients undergoing cytotoxic chemotherapy.
- Medicine, BiologyJournal of clinical oncology : official journal of the American Society of Clinical Oncology
- 2004
Prophylactic lamivudine significantly reduced the incidence of HBV reactivation and the overall morbidity of cancer patients undergoing chemotherapy.
Primary prophylaxis with lamivudine of hepatitis B virus reactivation in chronic HbsAg carriers with lymphoid malignancies treated with chemotherapy
- Medicine, BiologyBritish journal of haematology
- 2001
Primary prophylaxis with lamivudine may be a well tolerated and effective method to reduce the frequency of chemotherapy‐induced HBV reactivation in chronic HBsAg carriers.
Early is superior to deferred preemptive lamivudine therapy for hepatitis B patients undergoing chemotherapy.
- Medicine, BiologyGastroenterology
- 2003
Lamivudine should be considered preemptively before or at the initiation of chemotherapy for all hepatitis B surface antigen-positive lymphoma patients undergoing intense chemotherapy.
A randomized controlled study of preemptive lamivudine in patients receiving transarterial chemo‐lipiodolization
- Medicine, BiologyHepatology
- 2006
In conclusion, preemptive lamivudine therapy demonstrated excellent efficacy in reducing hepatitis due to HBV reactivation and hepatic morbidity during TACL and should be considered in HCC patients with an HBV DNA level of more than 104 copies/mL.
Extended lamivudine therapy against hepatitis B virus infection in hematopoietic stem cell transplant recipients.
- Medicine, BiologyBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
- 2006
Lamivudine in the treatment of hepatitis B virus reactivation during cytotoxic chemotherapy
- Medicine, BiologyJournal of medical virology
- 1999
In Hong Kong, where hepatitis B infection is endemic, it is proposed to screen all cancer patients for hepatitis B surface antigen before immunosuppressive/cytotoxic therapy, and to closely monitor liver function of those who are found to be HBsAg seropositive.
Steroid‐free chemotherapy decreases risk of hepatitis B virus (HBV) reactivation in HBV‐carriers with lymphoma
- Medicine, BiologyHepatology
- 2003
In conclusion, steroid‐free chemotherapy decreases the incidence and severity of HBV reactivation in HBsAg‐positive lymphoma patients, however, further research is needed to evaluate whether steroid-free chemotherapy may confer a less satisfactory control of lymphoma.
Lamivudine. A review of its therapeutic potential in chronic hepatitis B.
- Biology, MedicineDrugs
- 1999
Lamivudine inhibits HBV replication, reduces hepatic necro-inflammatory activity and the progression of fibrosis in patients with chronic hepatitis B, ongoing viral replication and compensated liver disease including HBeAg-negative patients.
Preemptive use of lamivudine reduces hepatitis B exacerbation after allogeneic hematopoietic cell transplantation
- Medicine, BiologyHepatology
- 2002
Preemptive use of lamivudine effectively reduced hepatitis due to exacerbation of HBV (adjusted hazards ratio, 0.09; P = .021).
Lamivudine prophylaxis for prevention of chemotherapy‐induced hepatitis B virus reactivation in hepatitis B virus carriers with malignancies
- Medicine, BiologyJournal of viral hepatitis
- 2004
Prophylactic lamivudine treatment in HBV carriers with haemato/oncological malignancy receiving chemotherapy prevents chemotherapy‐induced HBV reactivation.