Lamins A and C bind and assemble at the surface of mitotic chromosomes

  title={Lamins A and C bind and assemble at the surface of mitotic chromosomes},
  author={James R. Glass and Larry Gerace},
  journal={The Journal of Cell Biology},
  pages={1047 - 1057}
To study a possible interaction of nuclear lamins with chromatin, we examined assembly of lamins A and C at mitotic chromosome surfaces in vitro. When a postmicrosomal supernatant of metaphase CHO cells containing disassembled lamins A and C is incubated with chromosomes isolated from mitotic Chinese hamster ovary cells, lamins A and C undergo dephosphorylation and uniformly coat the chromosome surfaces. Furthermore, when purified rat liver lamins A and C are dialyzed with mitotic chromosomes… CONTINUE READING
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