Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction

@article{Nishimune2008LamininsPP,
  title={Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction},
  author={Hiroshi Nishimune and Gregorio Valdez and George Jarad and Casey L. Moulson and Ulrich Mueller and Jeffrey H Miner and Joshua R Sanes},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={182},
  pages={1201 - 1215}
}
A prominent feature of synaptic maturation at the neuromuscular junction (NMJ) is the topological transformation of the acetylcholine receptor (AChR)-rich postsynaptic membrane from an ovoid plaque into a complex array of branches. We show here that laminins play an autocrine role in promoting this transformation. Laminins containing the alpha4, alpha5, and beta2 subunits are synthesized by muscle fibers and concentrated in the small portion of the basal lamina that passes through the synaptic… CONTINUE READING