Laminin suppresses progesterone production by human luteinizing granulosa cells via interaction with integrin alpha 6 beta 1.

@article{Fujiwara1997LamininSP,
  title={Laminin suppresses progesterone production by human luteinizing granulosa cells via interaction with integrin alpha 6 beta 1.},
  author={Hiroshi Fujiwara and Tadashi Honda and Masamichi Ueda and Kazuto Nakamura and Shigetoshi Yamada and Michiyuki Maeda and Takahide Mori},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1997},
  volume={82 7},
  pages={2122-8}
}
We previously raised a murine monoclonal antibody (mAb), OG-1, against human granulosa cells (GC) and reported that human GC express the OG-1 antigen with the highest immunoreactivity during the periovulatory phase. Later, we showed that the OG-1 antigen is identical to human integrin alpha 6, and that human GC express integrin alpha 6 beta 1, but not alpha 6 beta 4. In the present study, we examined the expression of laminin (LN), the ligand for integrin alpha 6 beta 1. Flow cytometry showed… CONTINUE READING

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