Laminin regulates PI3K basal localization and activation to sustain STAT5 activation.

@article{Xu2010LamininRP,
  title={Laminin regulates PI3K basal localization and activation to sustain STAT5 activation.},
  author={Ren Xu and Virginia A. Spencer and Dinah Levy Groesser and Mina J. Bissell},
  journal={Cell cycle},
  year={2010},
  volume={9 21},
  pages={4315-22}
}
Extracellular matrix (ECM) is a key regulator of tissue morphogenesis and functional differentiation in the mammary gland. We showed recently that laminin-111 (LN1) together with prolactin induces β-casein expression in mammary epithelial cells (MECs) by sustaining STAT5 activation. Others have shown that Rac1 is required for integrin-mediated STAT5 activation, but molecules upstream of Rac1 remain to be elucidated. Here, we show that exposure to three-dimensional (3D) laminin-rich ECM (LrECM… CONTINUE READING
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