Laminin promotes neuritic regeneration from cultured peripheral and central neurons

  title={Laminin promotes neuritic regeneration from cultured peripheral and central neurons},
  author={Marston Manthorpe and Eva Engvall and Erkki Ruoslahti and Frank M Longo and George E Davis and Silvio Varon},
  journal={The Journal of Cell Biology},
  pages={1882 - 1890}
The ability of axons to grow through tissue in vivo during development or regeneration may be regulated by the availability of specific neurite-promoting macromolecules located within the extracellular matrix. We have used tissue culture methods to examine the relative ability of various extracellular matrix components to elicit neurite outgrowth from dissociated chick embryo parasympathetic (ciliary ganglion) neurons in serum-free monolayer culture. Purified laminin from both mouse and rat… CONTINUE READING


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