Laminin-induced Clustering of Dystroglycan on Embryonic Muscle Cells: Comparison with Agrin-induced Clustering

@article{Cohen1997LaminininducedCO,
  title={Laminin-induced Clustering of Dystroglycan on Embryonic Muscle Cells: Comparison with Agrin-induced Clustering},
  author={Monroe W. Cohen and Christian Jacobson and Peter D Yurchenco and Glenn E. Morris and Salvatore Carbonetto},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={136},
  pages={1047 - 1058}
}
The effect of laminin on the distribution of dystroglycan (DG) and other surface proteins was examined by fluorescent staining in cultures of muscle cells derived from Xenopus embryos. Western blotting confirmed that previously characterized antibodies are reactive in Xenopus. In control cultures, alphaDG, betaDG, and laminin binding sites were distributed as microclusters (<1 microm2 in area) over the entire dorsal surface of the muscle cells. Treatment with laminin induced the formation of… CONTINUE READING
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