Laminin and collagen IV subunit distribution in normal and neoplastic tissues of colorectum and breast.

@article{Hewitt1997LamininAC,
  title={Laminin and collagen IV subunit distribution in normal and neoplastic tissues of colorectum and breast.},
  author={Rachel E. Hewitt and Des Powe and Kristie Morrell and E. Balley and Iain H Leach and Ian O. Ellis and David R Turner},
  journal={British Journal of Cancer},
  year={1997},
  volume={75},
  pages={221 - 229}
}
To invade and metastasize, carcinomas must penetrate or lose their epithelial basement membrane (EBM), and then penetrate basement membranes (BMs) surrounding blood vessels, lymphatics, nerves and muscle cells. Knowledge of the composition of different BMs is necessary, so that appropriate antibodies and DNA probes are used to analyse these events. Laminin and type IV collagen are the principal BM components. However, recent studies show these two proteins exist in various isoforms, each of… CONTINUE READING

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