Laminin alpha2 deficiency and muscular dystrophy; genotype-phenotype correlation in mutant mice.

@article{Guo2003LamininAD,
  title={Laminin alpha2 deficiency and muscular dystrophy; genotype-phenotype correlation in mutant mice.},
  author={Ling Guo and Xiangmin Zhang and Wenhua Kuang and Haoxiang Xu and Ling A Liu and J T Vilquin and Yuko Miyagoe-Suzuki and Satoshi Takeda and Markus A. Ruegg and Ulla M. Wewer and Eva Engvall},
  journal={Neuromuscular disorders : NMD},
  year={2003},
  volume={13 3},
  pages={207-15}
}
Deficiency of laminin alpha2 is the cause of one of the most severe muscular dystrophies in humans and other species. It is not yet clear how particular mutations in the laminin alpha2 chain gene affect protein expression, and how abnormal levels or structure of the protein affect disease. Animal models may be valuable for such genotype-phenotype analysis and for determining mechanism of disease as well as function of laminin. Here, we have analyzed protein expression in three lines of mice… CONTINUE READING

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