Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells

@inproceedings{Miyazaki2012LamininEF,
  title={Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells},
  author={Takamichi Miyazaki and Sugiko Futaki and Hirofumi Suemori and Yukimasa Taniguchi and Masashi Yamada and Miwa Kawasaki and Maria Cristina Piumbato Innocentini Hayashi and Hideaki Kumagai and Norio Nakatsuji and Kiyotoshi Sekiguchi and Eihachiro Kawase},
  booktitle={Nature communications},
  year={2012}
}
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have the potential to provide an infinite source of tissues for regenerative medicine. Although defined xeno-free media have been developed, culture conditions for reliable propagation of hESCs still require considerable improvement. Here we show that recombinant E8 fragments of laminin isoforms (LM-E8s), which are the minimum fragments conferring integrin-binding activity, promote greater adhesion of hESCs and… CONTINUE READING
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