Laminin-Binding Integrins Induce Dll4 Expression and Notch Signaling in Endothelial Cells

@article{Estrach2011LamininBindingII,
  title={Laminin-Binding Integrins Induce Dll4 Expression and Notch Signaling in Endothelial Cells},
  author={Soline Estrach and Laurence Cailleteau and Cl{\'a}udio A. Franco and Holger Gerhardt and Caroline Stefani and Emmanuel Lemichez and Laurent Gagnoux-Palacios and Guerrino Meneguzzi and Amel Mettouchi},
  journal={Circulation Research},
  year={2011},
  volume={109},
  pages={172–182}
}
Rationale: Integrins play a crucial role in controlling endothelial cell proliferation and migration during angiogenesis. The Delta-like 4 (Dll4)/Notch pathway establishes an adequate ratio between stalk and tip cell populations by restricting tip cell formation through “lateral inhibition” in response to a vascular endothelial growth factor gradient. Because angiogenesis requires a tight coordination of these cellular processes, we hypothesized that adhesion, vascular endothelial growth factor… 

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