Laminin-5 induces osteogenic gene expression in human mesenchymal stem cells through an ERK-dependent pathway.

@article{Klees2005Laminin5IO,
  title={Laminin-5 induces osteogenic gene expression in human mesenchymal stem cells through an ERK-dependent pathway.},
  author={Robert F. Klees and Roman M. Salasznyk and Karl Kingsley and William H. A. Williams and Adele Ludin Boskey and George E. Plopper},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 2},
  pages={
          881-90
        }
}
The laminin family of proteins is critical for managing a variety of cellular activities including migration, adhesion, and differentiation. In bone, the roles of laminins in controlling osteogenic differentiation of human mesenchymal stem cells (hMSC) are unknown. We report here that laminin-5 is found in bone and expressed by hMSC. hMSC isolated from bone synthesize laminin-5 and adhere to exogenous laminin-5 through alpha3beta1 integrin. Adhesion to laminin-5 activates extracellular signal… CONTINUE READING

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