Laminin 332 in squamous-cell carcinoma

  title={Laminin 332 in squamous-cell carcinoma},
  author={Matt Peter Marinkovich},
  journal={Nature Reviews Cancer},
Basement membranes can be a barrier to tumour growth, but basement membrane molecules, including laminins, are also important autocrine factors produced by cancers to promote tumorigenesis. Many studies have shown the importance of laminin 332 (previously known as laminin 5) in this process, especially in squamous cell carcinoma. Through interactions with several cell-surface receptors (including α6β4 and α3β1 integrins, epidermal growth factor receptor and syndecan 1) and other basement… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 110 references

Integrin β 4 regulates migratory behavior of keratinocytes by determining laminin - 332 organization

N. Zahir
J . Biol . Chem . • 2006

β 4 integrin and epidermal growth factor coordinately regulate electric field - mediated directional migration via Rac 1

B. U. Sehgal
Mol . Biol . Cell • 2006

Prognostic implication of laminin - 5 gamma 2 chain expression in the invasive front of colorectal cancers , disclosed by area - specific four - point tissue microarrays

E. Shinto
Lab . Invest . • 2005

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