Laminar specific alterations of thalamocortical projections in organotypic cultures following layer 4 disruption in ferret somatosensory cortex
@article{Palmer2001LaminarSA, title={Laminar specific alterations of thalamocortical projections in organotypic cultures following layer 4 disruption in ferret somatosensory cortex}, author={Sidney L. Palmer and Stephen C. Noctor and Beata Jabłońska and Sharon L. Juliano}, journal={European Journal of Neuroscience}, year={2001}, volume={13} }
The developing neocortex influences the growth of thalamocortical projections. Layer 4 in particular receives the majority of input from the thalamus and is important in instructing thalamic afferents to terminate. Previous in vivo experiments demonstrated that disruption of layer 4 during corticogenesis in ferret somatosensory cortex by application of methylazoxy methanol acetate (MAM) prevents proper termination of thalamic afferents in appropriate cortical regions. To further explore the…
20 Citations
Disruption of layer 4 development alters laminar processing in ferret somatosensory cortex.
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It is concluded that normal thalamic terminations, an intact layer 4 and subsequent intracortical processing are integral to proper encoding of stimulus features.
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A model of cortical dysplasia in ferrets involving administration of methylaxozymethanol acetate to pregnant ferrets on gestational day 33, leading to dramatic reduction of layer 4 in the neocortex is developed and a direct correlation between increased GABAA and KCC2 expression with impaired migration and ability to explore the environment is shown.
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The importance of afferent innervation in the maturation of striatal neurons in organotypic cultures is demonstrated, as well as the importance of spontaneous and cortically evoked activity in striatal medium spiny neurons.
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