Laminar specific alterations of thalamocortical projections in organotypic cultures following layer 4 disruption in ferret somatosensory cortex

@article{Palmer2001LaminarSA,
  title={Laminar specific alterations of thalamocortical projections in organotypic cultures following layer 4 disruption in ferret somatosensory cortex},
  author={Sidney L. Palmer and Stephen C. Noctor and Beata Jabłońska and Sharon L. Juliano},
  journal={European Journal of Neuroscience},
  year={2001},
  volume={13}
}
The developing neocortex influences the growth of thalamocortical projections. Layer 4 in particular receives the majority of input from the thalamus and is important in instructing thalamic afferents to terminate. Previous in vivo experiments demonstrated that disruption of layer 4 during corticogenesis in ferret somatosensory cortex by application of methylazoxy methanol acetate (MAM) prevents proper termination of thalamic afferents in appropriate cortical regions. To further explore the… 
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20 Citations
Background Citations
11
Methods Citations
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Results Citations
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20 Citations

Disruption of layer 4 development alters laminar processing in ferret somatosensory cortex.

It is concluded that normal thalamic terminations, an intact layer 4 and subsequent intracortical processing are integral to proper encoding of stimulus features.

Alteration of interneuron migration in a ferret model of cortical dysplasia.

It is reported that GABA(A) receptor activation is crucial to the proper positioning of interneurons migrating into the cortex from the GE in normal and MAM-treated animals.

GABAA receptors reorganize when layer 4 in ferret somatosensory cortex is disrupted by methylazoxymethanol (MAM).

The redistribution of inhibitory receptors suggests that layer 4 plays an important role in regulating thalamic terminations and also in the resulting ability to refine processing of incoming stimuli.

N-Cadherin Regulates Ingrowth and Laminar Targeting of Thalamocortical Axons

Data indicate that N-cadherin has multifaceted roles in establishing the thalamocortical projection, governing aspects of both thalamic axon ingrowth and laminar targeting by acting as a layer IV stop signal, which progressively change in parallel with the maturational state of the cortex.

Targeted disruption of layer 4 during development increases GABAA receptor neurotransmission in the neocortex.

It is demonstrated that small amounts of toxins delivered during corticogenesis can result in long-lasting changes in ambient expression of GABAAR that influence intrinsic neuronal properties.

Altered migratory behavior of interneurons in a model of cortical dysplasia: the influence of elevated GABAA activity.

A model of cortical dysplasia in ferrets involving administration of methylaxozymethanol acetate to pregnant ferrets on gestational day 33, leading to dramatic reduction of layer 4 in the neocortex is developed and a direct correlation between increased GABAA and KCC2 expression with impaired migration and ability to explore the environment is shown.

Influence of radial glia and Cajal-Retzius cells in neuronal migration.

It is suggested that early interruption of cell division eliminates a population of cells and a factor important for maintaining proper cortical development, specifically providing cues maintaining elongation of radial glia.

Afferent influences on striatal development in organotypic cocultures

The importance of afferent innervation in the maturation of striatal neurons in organotypic cultures is demonstrated, as well as the importance of spontaneous and cortically evoked activity in striatal medium spiny neurons.

Experimentally-induced microencephaly: effects on cortical neurons

Interactions between TrkB Signaling and Serotonin Excess in the Developing Murine Somatosensory Cortex: A Role in Tangential and Radial Organization of Thalamocortical Axons

Mice lacking monoamine oxidase A (MAOA) display high levels of brain serotonin during the first postnatal week, causing an exuberant outgrowth of thalamocortical axons (TCAs) in layer IV of the…

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