Laminar shear stress regulates liver X receptor in vascular endothelial cells.

  title={Laminar shear stress regulates liver X receptor in vascular endothelial cells.},
  author={Minjia Zhu and Yi Fu and Yingjian Hou and Nanping Wang and You-fei Guan and Chaoshu Tang and John Y-J Shyy and Yi Zhu},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={28 3},
OBJECTIVE The liver X receptors (LXRs) regulate a set of genes involved in lipid metabolism and reverse cholesterol transport. We investigated the mechanism by which shear stress regulates LXR in vascular endothelial cells (ECs). METHODS AND RESULTS Western blot showed that the protein level of LXRalpha and its target ABCA1 in the mouse thoracic aorta was higher than that in the aortic arch. As well, the mRNA level of LXR and its target genes ABCA1, ABCG1, ApoE, and LPL in the thoracic aorta… CONTINUE READING


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