Laminar shear inhibits tubule formation and migration of endothelial cells by an angiopoietin-2 dependent mechanism.

@article{Tressel2007LaminarSI,
  title={Laminar shear inhibits tubule formation and migration of endothelial cells by an angiopoietin-2 dependent mechanism.},
  author={Sarah L. Tressel and Ruo-pan Huang and Nicholas Tomsen and Hanjoong Jo},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 10},
  pages={2150-6}
}
OBJECTIVE Fluid shear stress plays a role in angiogenesis. Laminar shear stress (LS) promotes endothelial cell (EC) quiescence, whereas oscillatory shear stress (OS) promotes EC turnover and dysfunction, which could lead to pathological angiogenesis. We hypothesized that LS inhibits EC migration and tubule formation, 2 functions important in angiogenesis, by inhibiting the secretion of proangiogenic factors. METHODS AND RESULTS Human umbilical vein ECs (HUVECs), human microvascular ECs (HMECs… CONTINUE READING