Laminar restriction of retinal macrophagic response to optic nerve axotomy in the rat.

@article{GarciaValenzuela1999LaminarRO,
  title={Laminar restriction of retinal macrophagic response to optic nerve axotomy in the rat.},
  author={E Garcia-Valenzuela and Sansar Chand Sharma},
  journal={Journal of neurobiology},
  year={1999},
  volume={40 1},
  pages={55-66}
}
Following optic nerve transection, most of the retinal ganglion cells die. Their debris is promptly cleared by phagocytic cells. It is currently not known to what extent peripherally derived macrophages contribute to this activity. Using antibodies OX42 and ED-1, phagocytic cells were labeled in the retinas of optic nerve lesioned adult rats. To distinguish whether the cells were reactive microglial or macrophagic in origin, blood-borne monocytes were labeled with fluorescent microspheres while… CONTINUE READING

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