Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis.

@article{Boirivant1999LaminaPT,
  title={Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis.},
  author={Monica Boirivant and Marco Marini and Gabriella di Felice and Anna Maria Pronio and Chiara Montesani and Roberto Tersigni and Warren Strober},
  journal={Gastroenterology},
  year={1999},
  volume={116 3},
  pages={557-65}
}
BACKGROUND & AIMS Normal human lamina propria lymphocytes manifest increased unstimulated apoptosis compared with peripheral lymphocytes, which are enhanced after stimulation via the CD2 activation pathway. This activation-induced apoptosis down-regulates cell expansion and cytokine production. In previous studies, it was shown that lamina propria T cells from patients with Crohn's disease and ulcerative colitis manifest abnormal proliferation and cytokine production. It was therefore of… CONTINUE READING