Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis.

Abstract

BACKGROUND & AIMS Normal human lamina propria lymphocytes manifest increased unstimulated apoptosis compared with peripheral lymphocytes, which are enhanced after stimulation via the CD2 activation pathway. This activation-induced apoptosis down-regulates cell expansion and cytokine production. In previous studies, it was shown that lamina propria T cells… (More)

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@article{Boirivant1999LaminaPT, title={Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis.}, author={Monica Boirivant and M. Marini and Gabriella Di Felice and Anna Maria Pronio and Chiara Montesani and Roberto Tersigni and Warren Strober}, journal={Gastroenterology}, year={1999}, volume={116 3}, pages={557-65} }