Lamina-associated polypeptide (LAP)2α and other LEM proteins in cancer biology.

  title={Lamina-associated polypeptide (LAP)2α and other LEM proteins in cancer biology.},
  author={Andreas Brachner and Roland Foisner},
  journal={Advances in experimental medicine and biology},
The LEM proteins comprise a heterogeneous family of chromatin-associated proteins that share the LEM domain, a structural motif mediating interaction with the DNA associated protein, Barrier-to-Autointegration Factor (BAF). Most of the LEM proteins are integral proteins of the inner nuclear membrane and associate with the nuclear lamina, a structural scaffold of lamin intermediate filament proteins at the nuclear periphery, which is involved in nuclear mechanical functions and (hetero… CONTINUE READING


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