Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans.

@article{Lee2002LamindependentLO,
  title={Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans.},
  author={Kenneth Ka-Ho Lee and Daniel A Starr and Merav Cohen and Jun Liu and Min Han and Katherine L. Wilson and Yosef Gruenbaum},
  journal={Molecular biology of the cell},
  year={2002},
  volume={13 3},
  pages={892-901}
}
Mutations in the Caenorhabditis elegans unc-84 gene cause defects in nuclear migration and anchoring. We show that endogenous UNC-84 protein colocalizes with Ce-lamin at the nuclear envelope and that the envelope localization of UNC-84 requires Ce-lamin. We also show that during mitosis, UNC-84 remains at the nuclear periphery until late anaphase, similar to known inner nuclear membrane proteins. UNC-84 protein is first detected at the 26-cell stage and thereafter is present in most cells… CONTINUE READING
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