Lamin A/C gene mutation associated with dilated cardiomyopathy with variable skeletal muscle involvement.

@article{Brodsky2000LaminAG,
  title={Lamin A/C gene mutation associated with dilated cardiomyopathy with variable skeletal muscle involvement.},
  author={Gary L. Brodsky and Francesco Muntoni and Snjezana Miocic and Gianfranco Sinagra and Caroline A. Sewry and Luisa Mestroni},
  journal={Circulation},
  year={2000},
  volume={101 5},
  pages={473-6}
}
BACKGROUND Dilated cardiomyopathy is a form of heart muscle disease characterized by impaired systolic function and ventricular dilation. Familial transmission of the disease is frequently observed, and genetic heterogeneity is indicated by clinical and morphological variability in the disease phenotype. In the family MDDC1 reported here, the disease phenotype is severe and characterized by an autosomal dominant pattern of transmission. In addition, the majority of affected family members show… CONTINUE READING

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