Lamin A/C Is a Risk Biomarker in Colorectal Cancer

  title={Lamin A/C Is a Risk Biomarker in Colorectal Cancer},
  author={Naomi D. Willis and Thomas R Cox and Syed F. Rahman-Casa{\~n}s and Kim M. Smits and Stefan Alexander Przyborski and Piet A van den Brandt and Manon van Engeland and Matty P Weijenberg and R Geoffrey Wilson and Adriaan P. de Bru{\"i}ne and Christopher J. Hutchison},
  journal={PLoS ONE},
  pages={848 - 858}
BACKGROUND A-type lamins are type V intermediate filament proteins encoded by the gene LMNA. Mutations in LMNA give rise to diverse degenerative diseases related to premature ageing. A-type lamins also influence the activity of the Retinoblastoma protein (pRb) and oncogenes such a beta-catenin. Consequently, it has been speculated that expression of A-type lamins may also influence tumour progression. METHODOLOGY/PRINCIPAL FINDINGS An archive of colorectal cancer (CRC) and normal colon tissue… CONTINUE READING


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