Lamellarin D: a novel potent inhibitor of topoisomerase I.


We report the identification and characterization of a novel potent inhibitor of DNA topoisomerase I: lamellarin D (LAM-D), initially isolated from a marine mollusk, Lamellaria sp., and subsequently identified from various ascidians. This alkaloid, which displays potent cytotoxic activities against multidrug-resistant tumor cell lines and is highly… (More)


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@article{Facompr2003LamellarinDA, title={Lamellarin D: a novel potent inhibitor of topoisomerase I.}, author={Micha{\"e}l Facompr{\'e} and Christelle Tardy and Christine Bal-Mahieu and Pierre Colson and Carlos P{\'e}rez and Ignacio Manzanares and Carmen Del Maria Cuevas and Christian Bailly}, journal={Cancer research}, year={2003}, volume={63 21}, pages={7392-9} }