Lambert–Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies

  title={Lambert–Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies},
  author={M. Titulaer and B. Lang and J. Verschuuren},
  journal={The Lancet Neurology},
  • M. Titulaer, B. Lang, J. Verschuuren
  • Published 2011
  • Medicine
  • The Lancet Neurology
  • Lambert-Eaton myasthenic syndrome (LEMS) is a neuromuscular autoimmune disease that has served as a model for autoimmunity and tumour immunology. In LEMS, the characteristic muscle weakness is thought to be caused by pathogenic autoantibodies directed against voltage-gated calcium channels (VGCC) present on the presynaptic nerve terminal. Half of patients with LEMS have an associated tumour, small-cell lung carcinoma (SCLC), which also expresses functional VGCC. Knowledge of this association… CONTINUE READING
    217 Citations
    The association between Lambert–Eaton myasthenic syndrome and small cell lung carcinoma
    • 2
    • Highly Influenced
    • PDF
    Lambert–Eaton myasthenic syndrome: Clinical review
    • 2
    • Highly Influenced
    • PDF
    Treatment options for Lambert–Eaton myasthenic syndrome
    Lambert-Eaton Myasthenic syndrome: early diagnosis is key
    • 5
    • PDF
    Lambert-Eaton Myasthenic Syndrome.
    • 11
    Lambert-Eaton Myasthenic Syndrome with A Twenty-Three-Year Delay in Diagnosis.
    • 2
    • PDF
    Pathologie dysimmunitaire de la jonction neuro-musculaire : le syndrome de Lambert-Eaton
    • PDF
    Italian recommendations for Lambert–Eaton myasthenic syndrome (LEMS) management
    • 12
    • Highly Influenced


    Lambert–Eaton Myasthenic Syndrome
    • 54
    Seronegative Lambert-Eaton myasthenic syndrome
    • 69
    The Eaton-Lambert syndrome in ocular myasthenia gravis.
    • S. Oh
    • Medicine
    • Archives of neurology
    • 1974
    • 34
    Transient neonatal Lambert–Eaton syndrome
    • B. Lecky
    • Medicine
    • Journal of Neurology, Neurosurgery & Psychiatry
    • 2006
    • 11
    [Eaton-Lambert syndrome associated with multiple myeloma: resolution of the neuromuscular block after chemotherapy].
    • 3
    Treatment for Lambert-Eaton myasthenic syndrome.
    • 105