Lambert–Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies

@article{Titulaer2011LambertEatonMS,
  title={Lambert–Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies},
  author={M. Titulaer and B. Lang and J. Verschuuren},
  journal={The Lancet Neurology},
  year={2011},
  volume={10},
  pages={1098-1107}
}
  • M. Titulaer, B. Lang, J. Verschuuren
  • Published 2011
  • Medicine
  • The Lancet Neurology
  • Lambert-Eaton myasthenic syndrome (LEMS) is a neuromuscular autoimmune disease that has served as a model for autoimmunity and tumour immunology. In LEMS, the characteristic muscle weakness is thought to be caused by pathogenic autoantibodies directed against voltage-gated calcium channels (VGCC) present on the presynaptic nerve terminal. Half of patients with LEMS have an associated tumour, small-cell lung carcinoma (SCLC), which also expresses functional VGCC. Knowledge of this association… CONTINUE READING
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