Lambda Int protein bridges between higher order complexes at two distant chromosomal loci attL and attR.

@article{Kim1992LambdaIP,
  title={Lambda Int protein bridges between higher order complexes at two distant chromosomal loci attL and attR.},
  author={Son A Kim and Arthur Landy},
  journal={Science},
  year={1992},
  volume={256 5054},
  pages={198-203}
}
The excisive recombination reaction of bacteriophage lambda involves a specific and efficient juxtaposition of two distant higher order protein-DNA complexes on the chromosome of Escherichia coli. These complexes, which mediate synapsis and strand exchange, consist of two DNA sequences, attL and attR, the bivalent DNA binding protein Int, and the sequence-specific DNA bending proteins, IHF, Xis, and Fis. The protein-protein and protein-DNA interactions within, and between, these complexes were… CONTINUE READING