Lambda CM8, a human sequence with putative centromeric function, does not map to the centromere but is present in one to two copies at 9qter.

@article{McGill1992LambdaCA,
  title={Lambda CM8, a human sequence with putative centromeric function, does not map to the centromere but is present in one to two copies at 9qter.},
  author={Niolette I. McGill and Judy A. Fantes and Howard J. Cooke},
  journal={Human molecular genetics},
  year={1992},
  volume={1 9},
  pages={749-51}
}
A DNA fragment isolated from a human genomic library, was reported to be present at all human centromeres and present at 16-32 copies per genome. Reintroduction of this DNA into mammalian cells as a concatenated phage clone gave rise to dicentric chromosomes which gave rise to a new, stable, chromosome. Taken together these observations could mean that this DNA is part of a native centromere. We have reexamined the location and copy number of this sequence and find it to be present at 1-2… CONTINUE READING

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