Lajollamycin, a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic from the marine actinomycete Streptomyces nodosus.

  title={Lajollamycin, a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic from the marine actinomycete Streptomyces nodosus.},
  author={Rama Rao Manam and Sy Teisan and Donald J. White and Benjamin Nicholson and Jennifer Grodberg and Saskia T. C. Neuteboom and Kin Sing Lam and Deborah A. Mosca and George Kenneth Lloyd and Barbara Christine Potts},
  journal={Journal of natural products},
  volume={68 2},
A strain of Streptomyces nodosus (NPS007994) isolated from a marine sediment collected in Scripps Canyon, La Jolla, California, was found to produce lajollamycin (1), a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic. The structure was established by complete analysis of spectroscopic data and comparison with known antibiotics oxazolomycin (2), 16-methyloxazolomycin (3), and triedimycin B (4). Lajollamycin (1) showed antimicrobial activity against both drug-sensitive and -resistant… 
Antitumor Compounds from Marine Actinomycetes
Actinomycetes are the producers of a large number of natural products with different biological activities, including antitumor properties, and have attracted special attention in the last years for their ability to produce interesting pharmacological lead compounds.
Novel anticancer compounds from marine actinomycetes : A Review
This review presents a total of 35 anticancer metabolites, belonging mainly to the structural class, which mainly emphasis on their biological activities of the antic cancer metabolites against cytotoxic cells isolated from marine actinomycetes from different places between January 2005 and December 2009.
Isolation, Purification and Partial Characterization of an Antibacterial Agent Produced by Halotolerant Alkaliphilic Streptomyces sp. EWC 7(2)
The spectroscopic studies showed that the molecule may be different from other known antibiotics produced by most closely related species of Streptomyces EWC 7(2), and further studies are required to elucidate the structure of the active compound.
Exploring the diversity and metabolic potential of actinomycetes from temperate marine sediments from Newfoundland, Canada
The potential for the discovery of novel bioactive metabolites from actinomycetes isolated from Atlantic Canadian marine sediments is demonstrated, including cytotoxic metabolites from Actinoalloteichus and Streptomyces.
Taxonomy and antimicrobial activity of moderately salt-tolerant and alkaliphilic Streptomyces sp. MN 9(V) isolated from solitary wasp mud nest
The strain MN 9(V) showed strong antimicrobial activity against several test organisms, including multidrug resistant bacteria, as well as against fungal pathogens.
1 Introduction to Marine Actinobacteria
Marine microbiology is developing strongly in several countries with a distinct focus on bioactive compounds. Analysis of the geographical origins of compounds, extracts, bioactivities, and
Anti-methicillin Resistant Staphylococcus aureus Compound Isolation from Halophilic Bacillus amyloliquefaciens MHB1 and Determination of Its Mode of Action Using Electron Microscope and Flow Cytometry Analysis
This is the first report on isolation of anti-MRSA compound from halophilic B. amyloliquefaciens MHB1 and could act as a promising biocontrol agent.
Research on marine actinobacteria in India
Of 9 maritime states of India, only 4 have been extensively covered for the study of marine actinobacteria, and most of the studies conducted pertain to isolation, identification and maintenance of these organisms in different culture media.
Discovery of Actinomycetes from Extreme Environments with Potential to Produce Novel Antibiotics
The research of the actinomycetes’ ability to produce antibiotics in the near-natural conditions provides a great opportunity to assess their biodiversity and distribution in the Central Asian region and to develop new methodological approaches to the screening of new antimicrobial agents.
Secretion of an alkaline protease from a salt- tolerant and alkaliphilic, Streptomyces clavuligerus strain Mit-1
An alkaliphilic and salt- tolerant actinomycete, Streptomyces clavuligerus strain Mit-1, was isolated from Mithapur, the western coast of India and produced substantial protease with various amino acids, when employed as the sole nitrogen sources.