Lajollamycin, a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic from the marine actinomycete Streptomyces nodosus.

@article{Manam2005LajollamycinAN,
  title={Lajollamycin, a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic from the marine actinomycete Streptomyces nodosus.},
  author={Rama Rao Manam and Sy Teisan and Donald J. White and Benjamin Nicholson and Jennifer Grodberg and Saskia T. C. Neuteboom and Kin Sing Lam and Deborah A. Mosca and George Kenneth Lloyd and Barbara Christine Potts},
  journal={Journal of natural products},
  year={2005},
  volume={68 2},
  pages={
          240-3
        }
}
A strain of Streptomyces nodosus (NPS007994) isolated from a marine sediment collected in Scripps Canyon, La Jolla, California, was found to produce lajollamycin (1), a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic. The structure was established by complete analysis of spectroscopic data and comparison with known antibiotics oxazolomycin (2), 16-methyloxazolomycin (3), and triedimycin B (4). Lajollamycin (1) showed antimicrobial activity against both drug-sensitive and -resistant… 
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