LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium.

@article{Dynes1994LagCIR,
  title={LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium.},
  author={J L Dynes and Adam Michael Clark and Gad Shaulsky and Adam Kuspa and William F. Loomis and Richard A. Firtel},
  journal={Genes & development},
  year={1994},
  volume={8 8},
  pages={948-58}
}
Strain AK127 is a developmental mutant of Dictyostelium discoideum that was isolated by restriction enzyme-mediated integration (REMI). Mutant cells aggregate normally but are unable to proceed past the loose aggregate stage. The cloned gene, lagC (loose aggregate C), encodes a novel protein of 98 kD that contains an amino-terminal signal sequence and a putative carboxy-terminal transmembrane domain. The mutant strain AK127 shows no detectable lagC transcript upon Northern analysis, indicating… CONTINUE READING