Laforin, defective in the progressive myoclonus epilepsy of Lafora type, is a dual-specificity phosphatase associated with polyribosomes.

Abstract

The progressive myoclonus epilepsy of Lafora type is an autosomal recessive disorder caused by mutations in the EPM2A gene. EPM2A is predicted to encode a putative tyrosine phosphatase protein, named laforin, whose full sequence has not yet been reported. In order to understand the function of the EPM2A gene, we isolated a full-length cDNA, raised an… (More)

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@article{Ganesh2000LaforinDI, title={Laforin, defective in the progressive myoclonus epilepsy of Lafora type, is a dual-specificity phosphatase associated with polyribosomes.}, author={S. Ganesh and Kishan Lal Agarwala and Kayo Ueda and Takashina Akagi and K. Kurozumi K. Shoda and Toru Usui and Tomoya Hashikawa and Hiroaki Osada and Antonio V Delgado-Escueta and Koichi Yamakawa}, journal={Human molecular genetics}, year={2000}, volume={9 15}, pages={2251-61} }