Corpus ID: 37899286

Laetrile: A wonder drug or farce?

  title={Laetrile: A wonder drug or farce?},
  author={Aakriti Bhatnagar and Samta Mittal and A. Garg},
  journal={International Journal of Applied Dental Sciences},
Cancer is one of the most feared diseases with exorbitant treatment costs which render the patients helpless, a condition in which alternative therapies come in the picture. A number of companies come up with a wide variety of agents which claim to cure cancer with lesser side effects and at a lower cost. One such drug is ‘Laetrile’, also known as ‘Amygdalin’ and popularly marketed as ‘Vitamin B17’. The effectiveness of this drug, however, is crucially questionable. The toxic effects of this… Expand
Amygdalin is considered one of the nitrilosides, natural cyanide containing substances abundant in the plants seeds of the prunasin family that have been used to treat cancers and also as painExpand
Understanding the mechanism of amygdalin’s multifunctional anti-cancer action using computational approach
Amygdalin revealed a supernatural behavior through the MD simulations: it revealed a further clarification of the mystery amygdalin’s experimental action which can act as a multifunctional drug in the cancer therapeutics. Expand
Amygdalin as multi-target anticancer drug against targets of cell division cycle: double docking and molecular dynamics simulation
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Molecular dynamics simulation, free energy landscape and binding free energy computations in exploration the anti-invasive activity of amygdalin against metastasis
Computer calculations revealed that amygdalin inhibits the selected targets via block the ATP-binding pocket of AKT1, FAK, and ILK by forming stable hydrogen bonds, and the decomposition of binding energy shows the pivotal amino acid residues responsible for the stability of Amygdalin's interactions inside the ATP -binding sites by forming hydrogen bonds. Expand
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Laetrile for cancer: a systematic review of the clinical evidence
The claim that laetrile has beneficial effects for cancer patients is not supported by sound clinical data, and none of these publications proved the effectiveness of laetrie. Expand
Laetrile treatment for cancer.
The claims that laetrile or amygdalin have beneficial effects for cancer patients are not currently supported by sound clinical data and the risk-benefit balance of laetRIle or Amygdalin as a treatment for cancer is unambiguously negative. Expand
Life-Threatening Interaction Between Complementary Medicines: Cyanide Toxicity Following Ingestion of Amygdalin and Vitamin C
This case highlights the fact that CAMs can produce life-threatening toxicity, and adds a further note of caution, namely, the potential for serious interactions between CAMs, particularly where there is no tradition of concomitant use. Expand
The current status of laetrile.
Acceptable clinical studies in humans are lacking, but such ventures would appear to be contraindicated from animal studies and observed human toxicities, and current legal-judicial aspects of laetrile therapy for cancer are discussed. Expand
Conjoint use of laetrile and megadoses of ascorbic acid in cancer treatment: possible side effects.
Individuals who have a reduced capacity to detoxify cyanide to thiocyanate are at increased risk to experience adverse side effects from laetrile, a cyanide containing substance used in cancerExpand
Amygdalin (Laetrile) and prunasin beta-glucosidases: distribution in germ-free rat and in human tumor tissue.
Observing the activity of beta-glucosidases that cleave glucose from amygdalin and from prunasin in tissues from germ-free rats and in normal and neoplastic human tissues poses serious questions concerning the alleged tumoricidal effect of Amygdalin. Expand
Glucuronides in anti-cancer therapy.
Glucuronide prodrugs have shown promising efficacy in anti-cancer therapy due to their increased specificity and reduced systemic toxicity. The prodrugs can be used in prodrug monotherapy (PMT),Expand
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1. Malononitriles did not inhibit the rhodanese activity in tissue homogenates, nor did they competitively displace the cyanide. 2. The rhodanese content of fetal tissue increased in amount withExpand
Effects of low cobalamin diet and chronic cyanide toxicity in baboons.
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Rhodanese–thioredoxin system and allyl sulfur compounds
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