Corpus ID: 37899286

Laetrile: A wonder drug or farce?

@article{Bhatnagar2017LaetrileAW,
  title={Laetrile: A wonder drug or farce?},
  author={Aakriti Bhatnagar and Samta Mittal and A. Garg},
  journal={International Journal of Applied Dental Sciences},
  year={2017},
  volume={3},
  pages={42-45}
}
Cancer is one of the most feared diseases with exorbitant treatment costs which render the patients helpless, a condition in which alternative therapies come in the picture. A number of companies come up with a wide variety of agents which claim to cure cancer with lesser side effects and at a lower cost. One such drug is ‘Laetrile’, also known as ‘Amygdalin’ and popularly marketed as ‘Vitamin B17’. The effectiveness of this drug, however, is crucially questionable. The toxic effects of this… Expand
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References

SHOWING 1-10 OF 20 REFERENCES
Laetrile for cancer: a systematic review of the clinical evidence
TLDR
The claim that laetrile has beneficial effects for cancer patients is not supported by sound clinical data, and none of these publications proved the effectiveness of laetrie. Expand
Laetrile treatment for cancer.
TLDR
The claims that laetrile or amygdalin have beneficial effects for cancer patients are not currently supported by sound clinical data and the risk-benefit balance of laetRIle or Amygdalin as a treatment for cancer is unambiguously negative. Expand
Life-Threatening Interaction Between Complementary Medicines: Cyanide Toxicity Following Ingestion of Amygdalin and Vitamin C
TLDR
This case highlights the fact that CAMs can produce life-threatening toxicity, and adds a further note of caution, namely, the potential for serious interactions between CAMs, particularly where there is no tradition of concomitant use. Expand
The current status of laetrile.
TLDR
Acceptable clinical studies in humans are lacking, but such ventures would appear to be contraindicated from animal studies and observed human toxicities, and current legal-judicial aspects of laetrile therapy for cancer are discussed. Expand
Conjoint use of laetrile and megadoses of ascorbic acid in cancer treatment: possible side effects.
Individuals who have a reduced capacity to detoxify cyanide to thiocyanate are at increased risk to experience adverse side effects from laetrile, a cyanide containing substance used in cancerExpand
Amygdalin (Laetrile) and prunasin beta-glucosidases: distribution in germ-free rat and in human tumor tissue.
TLDR
Observing the activity of beta-glucosidases that cleave glucose from amygdalin and from prunasin in tissues from germ-free rats and in normal and neoplastic human tissues poses serious questions concerning the alleged tumoricidal effect of Amygdalin. Expand
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Glucuronide prodrugs have shown promising efficacy in anti-cancer therapy due to their increased specificity and reduced systemic toxicity. The prodrugs can be used in prodrug monotherapy (PMT),Expand
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1. Malononitriles did not inhibit the rhodanese activity in tissue homogenates, nor did they competitively displace the cyanide. 2. The rhodanese content of fetal tissue increased in amount withExpand
Effects of low cobalamin diet and chronic cyanide toxicity in baboons.
TLDR
The results support the suggestions that cyanide affects bodily handling of Cbl and that hydroxo-cobalamin plays a part in detoxication of cyanide and suggest an inverse relationship between MMA excretion and plasma total Cbl. Expand
Rhodanese–thioredoxin system and allyl sulfur compounds
TLDR
An important involvement of the essential thioredoxin–thiOREDoxin reductase system in cancer cell cytotoxicity by organo‐sulfane sulfur compounds is suggested and the correlation between apoptosis induced by these compounds and the damage to the mitochondrial enzymes involved in the repair of the Fe–S cluster and in the detoxification system is highlighted. Expand
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