Lactulose--a drug with antiendotoxin effect.

  title={Lactulose--a drug with antiendotoxin effect.},
  author={H M Liehr and G Englisch and U Rasenack},
  volume={27 5},
Lactulose (beta-galactosido-fructose) was found to have anti-endotoxin properties: 670 mg lactulose abolished the gelating activity of mg E. coli endotoxin on Limulus lysate in vitro. When lactulose was fed to rats (6.3 +/- 1.1 g/kg/day) over a period of 4 or 8 days before i.v. administration of 0.5 g/kg galactosamine, the liver damage that normally develops was prevented. Since galactosamine-induced necrosis of hepatocytes and inflammatory reaction of the liver are mediated by systemic… CONTINUE READING

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