Lactosylceramide contributes to mitochondrial dysfunction in diabetes.

@article{Novgorodov2016LactosylceramideCT,
  title={Lactosylceramide contributes to mitochondrial dysfunction in diabetes.},
  author={Sergei A. Novgorodov and Christopher L. Riley and Jin Yu and Jarryd A Keffler and Christopher M. Clarke and An O Van Laer and Catalin F. Baicu and Michael R. Zile and Tatyana I. Gudz},
  journal={Journal of lipid research},
  year={2016},
  volume={57 4},
  pages={
          546-62
        }
}
Sphingolipids have been implicated as key mediators of cell-stress responses and effectors of mitochondrial function. To investigate potential mechanisms underlying mitochondrial dysfunction, an important contributor to diabetic cardiomyopathy, we examined alterations of cardiac sphingolipid metabolism in a mouse with streptozotocin-induced type 1 diabetes. Diabetes increased expression of desaturase 1, (dihydro)ceramide synthase (CerS)2, serine palmitoyl transferase 1, and the rate of ceramide… CONTINUE READING

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