Lactosylceramide beta-galactosidase in human sphingolipidoses. Evidence for two genetically distinct enzymes.

@article{Tanaka1975LactosylceramideBI,
  title={Lactosylceramide beta-galactosidase in human sphingolipidoses. Evidence for two genetically distinct enzymes.},
  author={Hiromitsu Tanaka and Kazuhiro Suzuki},
  journal={The Journal of biological chemistry},
  year={1975},
  volume={250 6},
  pages={2324-32}
}
In view of recent conflicting reports from two laboratories, activities of lactosylceramide beta-galactosidase were reinvestigated in detail in brains and livers of normal individuals and of patients with globoid cell leukodystrophy or GM1-gangliosidosis. Both sets of the apparently totally contradictory results were readily reproduced simply by using the different assay systems of the respective laboratories. With our own assay system, hepatic lactosylceramide beta-galactosidase appeared… CONTINUE READING

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