Lactose digestion and the evolutionary genetics of lactase persistence

  title={Lactose digestion and the evolutionary genetics of lactase persistence},
  author={C. Ingram and C. Mulcare and Y. Itan and Mark George Thomas and D. Swallow},
  journal={Human Genetics},
  • C. Ingram, C. Mulcare, +2 authors D. Swallow
  • Published 2008
  • Biology, Medicine
  • Human Genetics
  • It has been known for some 40 years that lactase production persists into adult life in some people but not in others. However, the mechanism and evolutionary significance of this variation have proved more elusive, and continue to excite the interest of investigators from different disciplines. This genetically determined trait differs in frequency worldwide and is due to cis-acting polymorphism of regulation of lactase gene expression. A single nucleotide polymorphism located 13.9 kb upstream… CONTINUE READING
    355 Citations

    Figures and Topics from this paper

    The Onset of Lactase Persistence in Europe
    • 16
    Evolutionary and molecular genetics of regulatory alleles responsible for lactase persistence
    • 1
    • Highly Influenced
    • PDF
    Genetic origins of lactase persistence and the spread of pastoralism in Africa.
    • 136
    • PDF
    Genetic diversity of lactase persistence in East African populations
    • 13
    Diversity of lactase persistence alleles in Ethiopia: signature of a soft selective sweep.
    • 75
    • PDF
    Evolution of lactase persistence: an example of human niche construction
    • 261
    • PDF


    The evolutionary genetics of lactase persistence in Africa and the Middle East
    • 5
    • PDF
    The lactase persistence/non-persistence polymorphism is controlled by a cis-acting element.
    • 93
    Convergent adaptation of human lactase persistence in Africa and Europe
    • 1,193
    • Highly Influential
    • PDF
    A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence?
    • 197
    • PDF
    The evolution of the lactase persistence phenotype
    • 19
    Lactase haplotype diversity in the Old World.
    • 184
    Absence of the lactase-persistence-associated allele in early Neolithic Europeans
    • 344
    • PDF
    Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans.
    • 149
    Microsatellite variation and evolution of human lactase persistence
    • 113
    • Highly Influential
    • PDF
    DNA Polymorphisms in the Lactase Gene
    • 43