Lactose causes heart arrhythmia in the water flea Daphnia pulex.

@article{Campbell2004LactoseCH,
  title={Lactose causes heart arrhythmia in the water flea Daphnia pulex.},
  author={Anthony K. Campbell and Kenneth T. Wann and Stephanie B Matthews},
  journal={Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology},
  year={2004},
  volume={139 2},
  pages={225-34}
}
The cladoceran Daphnia pulex is well established as a model for ecotoxicology. Here, we show that D. pulex is also useful for investigating the effects of toxins on the heart in situ and the toxic effects in lactose intolerance. The mean heart rate at 10 degrees C was 195.9+/-27.0 beats/min (n=276, range 89.2-249.2, >80% 170-230 beats/min). D. pulex heart responded to caffeine, isoproteronol, adrenaline, propranolol and carbachol in the bathing medium. Lactose (50-200 mM) inhibited the heart… CONTINUE READING

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The potent antibiotic ampicillin did not prevent the lactose inhibition , and two diols known to be generated by bacteria under anaerobic conditions were also without effect .
Lactose causes heart arrhythmia in the water flea Daphnia pulex .
Lactose causes heart arrhythmia in the water flea Daphnia pulex .
D. pulex heart responded to caffeine , isoproteronol , adrenaline , propranolol and carbachol in the bathing medium .
D. pulex heart responded to caffeine , isoproteronol , adrenaline , propranolol and carbachol in the bathing medium .
These effects were fully reversible by 3 - 4 h. Sucrose ( 100 - 200 mM ) also inhibited the heart rate , but glucose ( 100 - 200 mM ) and galactose ( 100 - 200 mM ) had no effect , suggesting that the inhibition by lactose or sucrose was not simply an osmotic effect .
These effects were fully reversible by 3 - 4 h. Sucrose ( 100 - 200 mM ) also inhibited the heart rate , but glucose ( 100 - 200 mM ) and galactose ( 100 - 200 mM ) had no effect , suggesting that the inhibition by lactose or sucrose was not simply an osmotic effect .
Lactose causes heart arrhythmia in the water flea Daphnia pulex .
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