Lactoperoxidase-catalyzed oxidation of melanin by reactive nitrogen species derived from nitrite (NO2-): an EPR study.

@article{Reszka1998LactoperoxidasecatalyzedOO,
  title={Lactoperoxidase-catalyzed oxidation of melanin by reactive nitrogen species derived from nitrite (NO2-): an EPR study.},
  author={K. Reszka and Z. Matuszak and C. Chignell},
  journal={Free radical biology \& medicine},
  year={1998},
  volume={25 2},
  pages={
          208-16
        }
}
The reaction of synthetic DOPA melanin (DM) with lactoperoxidase (LPO), hydrogen peroxide, and nitrite (NO2-) has been investigated using EPR. We observed that in the presence of nitrite LPO/H2O2 generated large amount of melanin radicals, as evidenced by a strong, up to 11-fold, increase in the intensity of the melanin EPR signal. In contrast, when nitrite was omitted the increase was much less, ca. 30%, which, nevertheless, indicates that DM can be metabolized directly by LPO/H2O2. When the… Expand
Mechanism of nitrite-stimulated catalysis by lactoperoxidase.
...
1
2
3
...

References

SHOWING 1-10 OF 45 REFERENCES
Reactive nitrogen intermediates and antimicrobial activity: role of nitrite.
  • S. Klebanoff
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 1993
Role of melanin as a scavenger of active oxygen species.
The effect of melanin on iron associated decomposition of hydrogen peroxide.
Interaction of radicals from water radiolysis with melanin.
...
1
2
3
4
5
...