Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation.

@article{Fujinaka2007LactogensPB,
  title={Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation.},
  author={Yuichi Fujinaka and Karen K Takane and Hiroko Yamashita and Rupangi Chhaya Vasavada},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 42},
  pages={30707-17}
}
One of the goals in the treatment for diabetes is to enhance pancreatic beta cell function, proliferation, and survival. This study explores the role of lactogenic hormones, prolactin (PRL) and placental lactogen (PL), in beta cell survival. We have previously shown that transgenic mice expressing mouse placental lactogen-1 (mPL1) in beta cells under the rat insulin II promoter (RIP) are resistant to the diabetogenic and cytotoxic effects of streptozotocin (STZ) in vivo. The current study… CONTINUE READING
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