Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN--gp120 interaction.

@article{Groot2005LactoferrinPD,
  title={Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN--gp120 interaction.},
  author={Fedde Groot and Teunis B H Geijtenbeek and Rogier W. Sanders and Christopher E Baldwin and Marta S{\'a}nchez-Hern{\'a}ndez and Ren{\'e} Floris and Yvette van Kooyk and Esther C. de Jong and Ben Berkhout},
  journal={Journal of virology},
  year={2005},
  volume={79 5},
  pages={3009-15}
}
One of the cell types first encountered by human immunodeficiency virus type 1 (HIV-1) following sexual transmission are dendritic cells (DC). DC capture HIV-1 through C-type lectin receptors, of which the best studied example is DC-SIGN, which mediates HIV-1 internalization. DC can keep the virus infectious for several days and are able to transmit HIV-1 to CD4(+) T cells. We tested proteins from milk and serum for their ability to block DC-mediated HIV-1 transmission, of which bovine… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 58 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Characterization of the anti-HIV effects of native lactoferrin and other milk proteins and protein-derived peptides

  • B. Berkhout, J. L. van Wamel, L. Beljaars, D. K. Meijer, S. Visser, R. Floris
  • Antiviral Res
  • 2002
Highly Influential
5 Excerpts

Antibacterial and antiviral effects of milk proteins and derivatives thereof

  • R. Floris, I. Recio, B. Berkhout, S. Visser
  • Curr. Pharm. Des
  • 2003
3 Excerpts

- specific ICAM - 3 receptor that supports primary immune responses

  • G. Vriend, Y. van Kooyk
  • 2002

Similar Papers

Loading similar papers…