Lactoferrin binds to cell membrane DNA. Association of surface DNA with an enriched population of B cells and monocytes.

@article{Bennett1983LactoferrinBT,
  title={Lactoferrin binds to cell membrane DNA. Association of surface DNA with an enriched population of B cells and monocytes.},
  author={Robert J. Bennett and John Y Davis and Stephen J Campbell and S Portnoff},
  journal={The Journal of clinical investigation},
  year={1983},
  volume={71 3},
  pages={611-8}
}
The binding of human 125I-labeled lactoferrin (LF) to a population of adherent mononuclear cells (ADMC) and nonrosetting lymphocytes (E-) was abolished by prior treatment of the cells with deoxyribonuclease (DNase), but not ribonuclease (RNase). When DNase-treated ADMC were incubated with exogenous DNA, the binding of 125I-LF was restored. Enzymatic digestion with other enzymes, trypsin, phospholipase D, and neuraminidase, did not significantly influence 125I-LF binding. Saturable binding of LF… CONTINUE READING

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