Lactoferrin and parathyroid hormone are not harmful to primary tenocytes in vitro, but PDGF may be.

@article{Musson2017LactoferrinAP,
  title={Lactoferrin and parathyroid hormone are not harmful to primary tenocytes in vitro, but PDGF may be.},
  author={David S Musson and Mei Lin Tay and Ashika Chhana and Bregina Pool and Brendan G. Coleman and Dorit Naot and Jillian Cornish},
  journal={Muscles, ligaments and tendons journal},
  year={2017},
  volume={7 2},
  pages={
          215-222
        }
}
Introduction Recently, bone-active factors such as parathyroid hormone and lactoferrin, have been used in pre-clinical models to promote tendon healing. How-ever, there is limited understanding of how these boneactive factors may affect the cells of the ten-don themselves. Here, we present an in vitro study assessing the effects of parathyroid hor-mone and lactoferrin on primary tendon cells (tenocytes), and compare their responses to the tenogenic factors, PDGF, IGF-1 and TGF-β. Materials… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

Advances in the use of growth factors for treatment of disorders of soft tissues.

  • Advances in experimental medicine and biology
  • 2014
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Effect of lactoferrin peptide (PXL01) on rabbit digit mobility after flexor tendon repair

J Hakansson, M Mahlapuu, L Ekstrom, K Olmarker, M. Wiig
  • The Journal of hand surgery
  • 2012
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Tendinopathy—from basic science to treatment

  • Nature Clinical Practice Rheumatology
  • 2008
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Delayed administration of recombinant huMuscles, Ligaments and Tendons

KR Duchman, JE Goetz, +3 authors AE Malandra
  • American Shoulder and Elbow Surgeons [et al]
  • 2016
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Does the Use of Platelet-Rich Plasma at the Time of Surgery Improve Clinical Outcomes in Arthroscopic Rotator Cuff Repair When Compared With Control Cohorts? A Systematic Review of Meta-analyses.

  • Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • 2016
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Hormones and tendinopathies: the current evidence.

  • British medical bulletin
  • 2016
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Preferential tendon stem cell response to growth factor supplementation.

  • Journal of tissue engineering and regenerative medicine
  • 2016
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL