Lactococcus lactis-expressing listeriolysin O (LLO) provides protection and specific CD8(+) T cells against Listeria monocytogenes in the murine infection model.

@article{BaheyElDin2008LactococcusLL,
  title={Lactococcus lactis-expressing listeriolysin O (LLO) provides protection and specific CD8(+) T cells against Listeria monocytogenes in the murine infection model.},
  author={M Bahey-El-Din and Pat G. Casey and Brendan T Griffin and Cormac G M Gahan},
  journal={Vaccine},
  year={2008},
  volume={26 41},
  pages={
          5304-14
        }
}
Lactococcus lactis has previously been proposed as a vaccine platform for the safe delivery of heterologous antigens. Here we utilized L. lactis as a live vector for expression of listeriolysin O (LLO), a major Listeria monocytogenes antigen and virulence factor. A variety of plasmid constructs were designed to permit either constitutive or nisin-inducible expression of secreted or non-secreted LLO in L. lactis. Recombinant strains were subsequently tested in a murine model for vaccination… CONTINUE READING
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