Lactobacillus reuteri prevents colitis by reducing P-selectin-associated leukocyte- and platelet-endothelial cell interactions.

@article{Schreiber2009LactobacillusRP,
  title={Lactobacillus reuteri prevents colitis by reducing P-selectin-associated leukocyte- and platelet-endothelial cell interactions.},
  author={Olof Schreiber and Joel Petersson and Mia Phillipson and Michael A. Perry and Simone Roos and Lena Holm},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2009},
  volume={296 3},
  pages={G534-42}
}
Recent findings indicate that dextran sodium sulfate (DSS)-induced colitis is associated with a prothrombogenic phenotype, with P-selectin playing a major role in platelet recruitment. It has been suggested that probiotics may ameliorate colonic inflammation. We therefore investigated how treatment with Lactobacillus reuteri influenced P-selectin expression, leukocyte and platelet endothelial cell interactions, and colitis severity in DSS-treated rats. Rats were divided into the following four… CONTINUE READING

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The role of P-selectin in experimental colitis as G541 LACTOBACILLUS REUTERI PREVENTS COLITIS AJP-Gastrointest Liver Physiol

  • M Gironella, M Molla, +6 authors J. Panes
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